A meta-analysis examines the effects of genetic polymorphisms on migraine susceptibility

Takeaway

  • In this meta-analysis, 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is shown to be associated with an increased risk for migraine with aura (MA) in Caucasians and total migraine risk in Asians.

Why this matters

  • The link between MTHFR C677T and A1298C polymorphisms and migraine susceptibility is ambiguous; here, the link between these polymorphisms and migraine subtypes provides further evidence that MA and migraine without aura (MO) are distinct disorders.