A role for TDP-43 in primary age-related tauopathy ?

Takeaway

  • TDP-43 is associated with atrophy of the amygdala, hippocampus and lateral and anterior temporal lobe in primary age-related tauopathy (PART).

Why this matters ?

  • The findings of this study suggest a pathological role for transactive response DNA-binding protein 43 (TDP-43) in neurofibrillary tangle-related diseases and should be considered when assessing patients with neurodegeneration.