Antagonism of transient receptor potential vanilloid 4 blocks mechanically-induced myotonia

Takeaway

  • Activation of transient receptor potential vanilloid 4 during muscle contraction in a mouse model plays a key role in triggering myotonia.

Why this matters

  • Existing myotonia therapies have limited tolerability and effectiveness.

  • These data are the first to demonstrate the existence of distinct molecular mechanisms triggering electrically- and mechanically-induced myotonia. Elimination of mechanically-induced myotonia by transient receptor potential vanilloid 4 inhibition represents a novel therapeutic approach.

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