Activation of transient receptor potential vanilloid 4 during muscle contraction in a mouse model plays a key role in triggering myotonia.
Why this matters
Existing myotonia therapies have limited tolerability and effectiveness.
These data are the first to demonstrate the existence of distinct molecular mechanisms triggering electrically- and mechanically-induced myotonia. Elimination of mechanically-induced myotonia by transient receptor potential vanilloid 4 inhibition represents a novel therapeutic approach.