Brain magnetic resonance imaging signs and dementia risk in non-cognitively impaired individuals

Takeaway

  • Smaller brain volumes in Alzheimer’s disease (AD) signature regions are independent risk factors for dementia in the non-cognitively impaired.

Why this matters

  • Prospective studies identifying magnetic resonance imaging (MRI) signs that are associated with the development mild cognitive impairment (MCI) and dementia are lacking, particularly in populations with nonimpaired cognition.