Takeaway
Cerebral microhemorrhages (CMHs) form part of the underlying disease process in dominantly inherited Alzheimer’s disease (DIAD) and are significantly associated with dementia.
Why this matters
CMHs are commonly observed in older adults, but it can be difficult to discriminate etiology in this group since they often have mixed pathologies; as such, investigating CMH’s in a younger, at-risk cohort such as those with DIAD, may be useful.
The role of CMHs in DIAD may constitute a potentially important imaging marker of disease risk and may influence treatment options for patients as well as their selection in clinical trials for this specific condition; however, further study is warranted for greater clarity.