Characterizing the pathological effects of alpha-synuclein on the striatal network

Takeaway

  • Alpha-synuclein (α-syn) impairs long-term potentiation (LTP) in striatal spiny projection neurons (SPN) and causes visuospatial learning deficit, acting through an interaction with GluN2A-bearing N-methyl--aspartate (NMDA) receptor.

Why this matters

  • The finding that the detrimental effects of α-syn could be countered by antibodies against α-syn present an approach to preserve synaptic plasticity in the striatal network.