Clinical heterogeneity of migraine with aura imaging profiles linked to thalamo-cortical morpho-functional features


  • The two clinical phenotypes of migraine with aura, pure visual auras and complex neurological auras, have common and distinct morpho-functional features of nodes in the thalamo-cortical network.

Why this matters

  • It has been suggested that migraine with aura is a heterogeneous condition where different pathophysiological mechanisms underlie the continuum in clinical phenotype.

  • This novel study captured the magnetic resonance imaging (MRI) functional hemodynamics of the cortex at rest to quantify functional connectivity.

  • Better understanding of the underlying differences between the two subtypes of migraine with aura could ultimately lead to better, more targeted interventions.