Takeaway
Depending on the phenotype, patients with adult-onset X-linked adrenoleukodystrophy (X-ALD) showed differences in cognitive function in various domains, including processing speed, attention and learning.
Why this matters
X-ALD is a rare genetic disorder with a varied adult-onset phenotype, from mild myelopathic forms (adrenomyeloneuropathy [AMN]) to severe cerebral variants (adult cerebral adrenoleukodystrophy [ACALD]).
More information on cognitive function in adult-onset X-ALD phenotypes would help inform treatment decisions and prognosis.