Deep brain stimulation of the subthalamic nuclei in diphasic dyskinesia


  • Deep brain stimulation (DBS) of bilateral subthalamic nucleus (STN) is effective in controlling diphasic dyskinesia.

Why this matters

  • Diphasic dyskinesia is an involuntary, difficult-to-treat movement appearing at the beginning and end of levodopa treatment in PD patients; as such, clinicians have suggested treatment with STN DBS, an established treatment for other PD-associated motor complications.

  • The effective remediation of diphasic dyskinesia by STN DBS adds support to already-existing studies with similar findings, and may guide development of other, potentially less-invasive therapies targeting the STN, consequently improving patient quality of life.