Differences in functional magnetic resonance imaging (fMRI) signals in patients with migraine


  • Contrasting patterns of brain signal variation and dynamic functional connectivity (dFC) within the thalamo-cortical and frontoparietal pathways could be linked to abnormal network integrity and instability for pain transmission and modulation in patients with migraine.

Why this matters

  • Patients with migraine exhibit abnormal cortical dFC between the posterior thalamus, default mode and visual regions, but the temporal dynamics of brain activity and neural communication during the interictal period and its clinical significance for migraine attacks have not been elucidated.

  • This study used resting-state blood-oxygen-level-dependent signal variability (BOLDSV) to reveal altered cortical activity and network dynamics that impact migraine attack and pain in patients who experience episodic and chronic migraine.

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