Effects of globus pallidus internus stimulation on camptocormia in people with Parkinson’s disease


  • In people with camptocormia due to Parkinson’s disease (PD), deep brain stimulation (DBS) of the globus pallidus internus (GPi) improved camptocormia angle. The improvements were positively associated with responsiveness to levopoda treatment, large pre-surgical angles, and high structural connectivity.

Why this matters

    People with PD commonly experience camptocormia, a postural deformity with few available treatments. Prior studies have demonstrated the efficacy of subthalamic nucleus (STN)-DBS in improving abnormal posture, and although the GPi is a main target of DBS, the efficacy of GPi-DBS to treat camptocormia has not been fully investigated.