Hippocampal pathology in temporal lobe epilepsy modulates connectome topology and controllability

Takeaway

  • In temporal lobe epilepsy (TLE), severe hippocampal sclerosis (HS) is associated with marked alterations of network topology and reduced controllability, while isolated gliosis (G) showed only subtle changes.

Why this matters

  • The authors provide new evidence that variations in mesiotemporal pathology are key determinants of whole-brain structural network alterations and structurally governed functional dynamics.