Identification of a plasma metabolomic signature for migraine

Takeaway

  • Migraine is associated with decreased apolipoprotein A1 (apoA1), an apoprotein specifically associated with high-density lipoprotein (HDL), and free cholesterol to total lipid ratio in small HDL (S-HDL-FC), as well as decreased omega-3 fatty acids in men only.

Why this matters

  • Identifying circulating biomarkers for migraine might provide insights into its molecular signature and, potentially, its relationship with cerebrovascular and cardiovascular disease.