Takeaway
This pilot study on epitope diagnostics for multiple sclerosis (MS) identifies novel immunological disease features using unbiased mimotope variation analysis (MVA).
Why this matters
Optic neuritis (ON) can occur in isolation or develop into MS; however, predictive factors of this progression remain poorly understood, as do the central nervous system (CNS) antigens targeted by T and B cells in MS.
The identification of novel disease features highlights the importance of understanding immunoreactivity at the epitope level in MS to aid current and future efforts towards personalized treatment development.