In hyposmic subjects with isolated REM sleep behavior disorder, impaired prosody precedes nigrostriatal dopaminergic transmission defects


Background: Impairments of olfactory and speech function are likely early prodromal symptoms of α-synucleinopathy.

Objective: The aim of this study is to assess whether dysprosody is present in isolated rapid eye movement sleep behavior disorder (iRBD) with hyposmia/anosmia and a normal nigrostriatal system.