Investigating the therapeutic mechanism underlying seizure control after responsive neurostimulation

Takeaway

  • This study provides the first set of results that demonstrate that there are certain electrophysiological signatures associated with specific therapeutic responses to neurostimulation (closed-loop brain stimulation) in patients with focal epilepsy.

  • The therapeutic outcomes appear to result from changes in the seizure network over time rather than acute disruption of single seizure events.

Why this matters

  • There is evidence portraying that responsive neurostimulation (RNS) improves seizure control and quality of life in patients with focal epilepsy, however the mechanisms underlying these observations remain unclear.