Key network node in temporal lobe epilepsy: The nucleus basalis of Meynert

Takeaway

  • The nucleus basalis of Meynert (NBM) key network structure is markedly perturbed in patients with temporal lobe epilepsy (TLE) and may underlie the broad pathophysiology of TLE.

Why this matters

  • Patients with temporal lobe epilepsy who experience seizures typically demonstrate neurocognitive deficits in domains not related to mesial temporal function. This suggests a common subcortical source of network dysfunction in TLE.

  • The NBM plays an important role in arousal, influences neurocognition and is anatomically associated with limbic structures, all which may help regulate functional networks.