Meta-analysis reveals two genetic variants that increase risk of late-onset Alzheimer’s disease

Takeaway

  • Variations in PINX1 and TREM2, involved in DNA aging and neurodegeneration, are linked to an increased risk of late-onset Alzheimer’s disease (LOAD) across ethnicities.

Why this matters

  • Rare genetic variants that may have a large effect on LOAD risk but are difficult to detect due to their low frequency and tendency to be ethnicity-specific; computational meta-analyses may facilitate understanding of these, improving the identification of therapeutic targets.