Metabolic biomarkers for post-spinal cord injury pain

Takeaway

  • Choline containing compounds are a promising metabolic biomarker for development of neuropathic pain (NP) in patients with spinal cord injury (SCI).

Why this matters

  • NP arises as a complication of SCI in ~50% of patients.

  • Previous studies have found high levels of neurodegenerative and neuroinflammatory metabolites in patients with SCI with NP; however, changes in metabolites in the cervical cord during spinal injury are understudied.