Microglial activation, inflammation, and development of α-synuclein pathology

Takeaway

  • Inflammation and microglial activation were detected long before emergence of α-synuclein pathology in implanted dopamine neurons in patients with advanced Parkinson’s disease (PD).

Why this matters

  • Sustained microglial activation prior to onset of α-synuclein pathology indicates that it may have a causative role in the proliferation and spread of α-synuclein pathology, and may serve as a disease-modifying therapeutic target in PD.