Midlife subclinical atherosclerosis affects cognitive function with discrepancies across races


  • Independent of major cardiovascular risk factors, subclinical atherosclerosis (as measured by carotid intima-media thickness [c-IMT]), is associated with worse cognitive function.

Why this matters?

  • Arterial stiffening and atherosclerosis of large arteries can impact blood flow to the brain, eventually leading to neuronal damage and neurodegeneration, and can serve as a marker of emerging Alzheimer’s disease or related dementias.

  • The effects of midlife c-IMT on cognition has not been well-studied, with midlife being a less studied, yet critical, time-window for the early pathogenesis of dementia.