Multiple concussions associated with increased risk of elevated cerebrospinal fluid tau levels

Takeaway

  • Former athletes who experienced multiple concussions are at increased risk of elevated cerebrospinal fluid (CSF) levels tau, which is associated with decreased white matter (WM) integrity and reduced cognitive function.

Why this matters

  • The ability to treat post-concussion degeneration, such as chronic traumatic encephalopathy (CTE), is dependent on being able to detect in vivo pathology early before the disease progresses to an irreversible stage.