Neurogenesis, improved locomotion and reduced anxiety in a mouse model of Alzheimer’s disease

Takeaway

  • Improved locomotor activity and reduced anxiety and increased neurogenesis can be observed in mice in the early stages of Alzheimer’s disease (AD) following exposure to an enriched environment (EE); whereas cognition remains unaffected.

Why this matters

  • Behavioral, psychological and personality symptoms are known to occur early in AD and may play a role in pathogenesis; understanding the impact of environmental factors on disease progression may help in the development of treatment strategies.