Neuromelanin content and striatal dopaminergic function in Parkinson’s disease

Takeaway

  • Reduction of neuromelanin content in the substantia nigra pars compacta (SNc) in Parkinson’s disease (PD) only correlates with loss of striatal dopaminergic function in the clinically most-affected side of the brain.

Why this matters

  • The uneven pattern of association between SNc pigmentation and striatal dopaminergic function indicates a lag in disease progression or various pathological processes underlying PD.