Neuromuscular junctions offer insight into split-hand syndrome in amyotrophic lateral sclerosis

Takeaway

  • Activity at neuromuscular junctions in hand muscles can be important as a susceptibility factor in predominant early involvement in amyotrophic lateral sclerosis (ALS).

Why this matters

  • Investigating the transmission of signals at the neuromuscular junction can help elucidate some of the underlying pathology of ALS and indicate susceptibility to neurogenic change.