Novel disease-associated variants in LAMP3 and BST1 with rapid eye movement sleep behavior disorder

Takeaway

  • Rare coding genetic variants in BST1 and rare non-coding variants in LAMP3 are linked to isolated rapid eye movement (REM) sleep behavior disorder.

Why this matters

    This is the largest genetic study of isolated REM sleep behavior disorder to date. The novel findings suggest that loss-of-function of BST1 could be a novel therapeutic target for this disorder.

International Medical Press is a global provider of independent medical education. Its mission is to provide healthcare professionals with high-quality, trusted medical information with the aim of helping optimize patient care.

No responsibility is assumed by International Medical Press for any injury and/or damage to persons or property through negligence or otherwise, or from any use or operation of any methods, products, instructions, or ideas contained in the material herein. Because of rapid advances in the medical sciences, International Medical Press recommends that independent verification of diagnoses and drug dosages should be made. The opinions expressed do not reflect those of International Medical Press or the sponsor. International Medical Press assumes no liability for any material contained herein.