People with Rett syndrome are likely to have severe and multiple types of hand stereotypies

Takeaway

  • Hand stereotypies (HS) are present with high frequency/severity in most people with classic and atypical Rett syndrome (RTT) with hand mouthing and clapping/tapping decreasing over time.

Why this matters

    HS are a defining feature in RTT that manifests as partial or complete loss of hand function or language, and impaired gait and improved understanding of the natural history of HS is critical to diagnosis and prognosis, and investigating the efficacy of interventions.