Postmortem insights into protein pathologies in frontotemporal lobar degeneration

Takeaway

  • Autopsy confirmed that there are divergent protein pathologies in frontotemporal lobar degeneration (FTLD) with TDP-43 (FTLD-TDP) or tau (FTLD-tau) that are associated with language features.

Why this matters

  • The distinct patterns of regional cortical pathology in FTLD, and their associated language features, may help improve diagnosis of FTLD pathologies.