Programmed cell death protein 1 signaling in immune-mediated myopathies

Takeaway

  • T-cell dysfunction and activation of the programmed cell death protein 1 (PD1) pathway are implicated in the development of immune-mediated myopathies.

Why this matters

    This is the first evidence for T-cell and PD1 involvement in immune-mediated myopathies, guiding novel understanding of the disease pathogenesis and revealing new potential drug targets.