Sex-specific differences in pain: different responses reveal different underlying mechanisms

Preclinical evidence is shedding light on the underlying mechanisms of sex-specific differences in pain.

“It’s widely acknowledged that many different pain states – migraine included – are more common in women,” said Dr Gregroy Dussor of the University of Texas in Dallas, Texas, USA. Interest in sex differences in pain has increased recently, and emerging evidence from preclinical studies has confirmed multiple differences between sexes.