Soluble β-amyloid is associated with cognitive decline independently of β-amyloid deposits.

Takeaway

  • Soluble β-amyloid is associated with accelerated cognitive decline in Alzheimer’s disease (AD) and mild cognitive impairment (MCI).

Why this matters

    Recent evidence indicates a strong link between soluble β-amyloid and cognitive decline in AD. It is not yet known whether this link is independent of the presence of insoluble cortical β-amyloid deposits. Understanding the pathophysiology behind dementia will enable the development of better targeted therapies.