Targeting radiotherapy-resistant cells in glioblastoma


  • The NF-κB-YY1-miR-103a regulatory axis is a key mechanism of radioresistance in glioblastoma (GBM) cells and could represent a novel therapeutic target.

Why this matters ?

  • Repopulation of tumors by surviving cells is the key mechanism of radiotherapy failure in GBM.

  • Identifying druggable mechanisms of radioresistance is key to reducing recurrence rates and may provide better outcomes than simply increasing radiation dose.