Takeaway
The NF-κB-YY1-miR-103a regulatory axis is a key mechanism of radioresistance in glioblastoma (GBM) cells and could represent a novel therapeutic target.
Why this matters ?
Repopulation of tumors by surviving cells is the key mechanism of radiotherapy failure in GBM.
Identifying druggable mechanisms of radioresistance is key to reducing recurrence rates and may provide better outcomes than simply increasing radiation dose.