Transcriptomic and genetic analyses in intractable partial epilepsy

Takeaway

  • In whole (gene and exon-level) transcriptome analysis on cortical tissue samples, a large number of genes are differently expressed or spliced between patients with mesial temporal lobe epilepsy with hippocampal sclerosis and healthy controls.

Why this matters

  • These data facilitate identification of new genetic risk variants and potential therapeutic targets that could influence epilepsy and pharmacoresistance, increasing understanding of seizure susceptibility.