Validation of patient-reported outcomes with the Migraine-Specific Quality of Life questionnaire


  • All three domains of the Migraine-Specific Quality of Life questionnaire version 2.1 electronic patient-reported outcome (MSQ v2.1 ePRO) demonstrate sufficient validity, reliability, responsiveness and appropriate interpretation standards in patients with chronic (CM) or episodic migraine (EM).

Why this matters

  • The 14-item MSQ v2.1 ePRO comprises three domains: Role Function-Restrictive (RFR), Role Function-Preventive (RFP) and Emotional Function (EF), and has gradually gained clinical recognition, even being used in Phase 3 trials due to its focus on migraine-specific aspects.

  • Utilization of a reliable, accessible tool may reduce unnecessary travel to clinical settings for patients with migraine-induced disability burden; in addition, clinical services are increasingly moving to digital platforms, particularly in view of the COVID-19 pandemic.

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